Disease Annotated Chromatin Epigenetic Resource
Network visualization in your browser.
Curated Yeast Complexes
Consolidated protein interactions from many source DBs.
Cytoscape plug-in for high-throughput genetic interactions
Linear layout for network analysis
Cytoscape visualization plugin
Local Coherence Detection: Biclustering for data analysis
Cytoscape plugin for network comparisons between organisms.
Yeast TAP/MS derived PPI & complexes with a membrane protein focus.
Search for intertwined protein structures
Proteins are some of the most fascinating and complex macromolecules in living systems that play extraordinarily diverse roles in sustaining life. These roles are mediated through the interactions that proteins make both with themselves and with other molecular constituents of the cell.
The focus of our laboratory is on investigating the principles that govern these interactions. We use molecular simulation and modeling techniques to study protein-protein protein-DNA and protein-ligand interactions at the atomic scale. We furthermore analyze the properties of known protein structures and sequences in order to gain insight into how evolution has shaped the functional specificity of proteins.
In parallel to these molecular level investigations we are actively engaged in developing quantitative and integrative computational approaches for analyzing physical and functional interactions between proteins, protein complexes and biochemical pathways at the cellular level. All our research activities closely combine the development of methods and software tools with their application to important biological problems with relevance to human health.
Donaldson Group | Emili Lab |
Greenblatt Lab | Parkinson Lab |
Tyers Lab | Zhang Lab |