The analysis of genetic and physical interaction data, generated by high-throughput studies, has become increasingly challenging, necessitating feature-rich analysis and visualization tools to extract meaningful information from the sizable data. GIPro is a Cytoscape plugin developed to allow integrative analysis and visualization of high-throughput genetic and physical interaction data in the context of protein complexes.
There are three main components to the plugin:
- Enrichment analysis, which highlights complexes or pairs of protein complexes with
a significant number of genetic interactions, unlikely to occur by chance.
- Visualization of interaction data in context of protein complexes,
which allows groups of functionally related proteins to be viewed as a
grouped node. These nodes can be expanded to display underlying proteins and
their genetic/physical interactions.
- Visualization of raw genetic interaction data as well as correlation and genetic interaction profiles
of different gene groups.
