Linking the molecular and cellular levels:
Bioinformatics & computational structural
biology at the Wodak Lab.
Proteins are some of the most fascinating and
complex macromolecules in living systems that play extraordinarily
diverse roles in sustaining life. These roles are mediated through the
interactions that proteins make with both with themselves and other
molecular constituents of the cell.
The focus of our laboratory is on investigating
the principles that govern these interactions. We use molecular
simulation and modeling techniques to study protein-protein
,
protein-DNA
and protein-ligand
interactions at the
atomic scale. We furthermore analyze the properties of known protein
structures and sequences in order to gain insight into how evolution has
shaped the functional specificity
of proteins.
In parallel to these molecular level
investigations we are actively engaged in developing quantitative and
integrative computational approaches
for analyzing physical and functional interactions between protein
interactions,
protein complexes and biochemical pathways
at the cellular level. All
our research activities closely combine the development of methods and
software tool with their application to important biological problems
with relevance to human health.
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