nef NP_057857 - HIV-1 M:B_HXB2R - iRefWeb - Wodak Lab

nef — NP_057857 — HIV-1 M:B_HXB2R

Negative factor. An HIV-1 viral accessory protein important for virus replication in vivo and is a determinant of HIV-1 pathogenesis. Nef down-regulates cell surface CD4 and MHC class 1 molecules and enhances viral infectivity through interations with multiple cellular signalling proteins.

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