About - iRefWeb - Wodak Lab

iRefWeb is an interface to a relational database containing the latest build of the interaction Reference Index (iRefIndex) which integrates protein interaction data from eleven different interaction databases: BioGRID, BIND, CORUM, DIP, HPRD, INTACT, MINT, MPPI, MPACT, OPHID and BINDTranslation.

Integration is achieved through a rigorously documented procedure for mapping protein IDs across databases, enabling systematic backtracking of the links used to establish the identity of the interaction partners.

The iRefWeb interface groups interaction records from the different databases into a single non-redundant view. In particular iRefWeb facilitates comparing interaction records as seen by the various source databases relative to the PubMeds they were annotated from.

iRefWeb is one of several views of the iRefIndex resource. Data are also available in a tab-delimited plain-text format (PSI-MITAB) as well as planned releases of a PSI-XML formatted version and a Cytoscape plugin. Further details about the iRefIndex project as well as data downloads are available from here . The method used to build iRefIndex is described in a recent publication which in addition to what is described in the paper, now includes a further refinement of canonicalization of isoforms.

Credits

The iRefWeb interface and underlying database is a collaborative effort between the Donaldson research group at the University of Oslo, Norway and the Wodak Lab at the Hospital for Sick Children in Toronto, Canada.

• Emerson Cho
• Edgar Crowdy
• Ian Donaldson
• Kyle Morrison
• Sabry Razick
• Andrei Turinsky
• Brian Turner
• Shoshana Wodak

Feedback

Brian Turner for matters related to iRefWeb
Ian Donaldson for matters related to iRefIndex